The FDA created a reporting system for doctors and health professionals to use in 1998 in order to report adverse and fatal drug reactions. A list of the top harmful drugs has been published showing that painkillers cause the most injuries. Clozapine is in the top five and it is an antipsychotic drug. The system is called MedWatch.
Five of the top six drugs causing deaths were painkillers: Oxycontin, Fentanyl, morphine, acetaminophen and methadone. The sixth was the antipsychotic drug Clozapine.
Among the drugs causing the most nonfatal adverse events were estrogens, insulin, interferon beta, Paroxetine, Clozapine, Oxycontin, warfarin and Fentanyl. Paroxetine is an antidepressant, interferon beta is used to treat multiple sclerosis and cancer, and warfarin is an anti-clotting agent.
Doctors and patients should review prescribing and dosing information for these drugs and follow them closely.